Research progress in cellular pharmacokinetics of nano-drug delivery systems
10.16438/j.0513-4870.2018-0456
- VernacularTitle:纳米药物递送系统的细胞药代动力学研究进展
- Author:
Xing WANG
1
;
Yao-qi WANG
1
;
Qiang ZHANG
1
;
Chong-qin YI
2
;
Xue-qing WANG
1
Author Information
1. School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
2. Founder Medical Research Institute Co., Ltd., Beijing 102206, China
- Publication Type:REVIEWS
- Keywords:
nano-drug delivery system;
cellular pharmacokinetics;
analytical method
- From:
Acta Pharmaceutica Sinica
2018;53(10):1620-1629
- CountryChina
- Language:Chinese
-
Abstract:
Nano-drug delivery systems (nano-DDS) are the hotspots of new drug delivery systems, which have many advantages, such as sustained and controlled release, targeting delivery. Traditional pharmacokinetics are difficult to predict the efficacy of drugs in vivo sometimes. It is urgently needed to extend the traditional pharmacokinetics studies to the cell/subcellular level and perform cell pharmacokinetic studies. The study on the pharmacokinetics of nano-DDS helps us to elucidate the mechanism of the actions of them in cells and guides us to design and develop nano-DDS more reasonably. This article summarizes the research content and methods on the cellular pharmacokinetics of nano-DDS, in order to provide an important reference for the early stage design of nano-DDS.
