Cucurbitane-type triterpenoids from the tubers of Hemsleya dolichocarpa
10.16438/j.0513-4870.2018-0526
- VernacularTitle:长果雪胆块茎中的葫芦烷三萜类化学成分研究
- Author:
Hua WEI
1
;
Yi-han LIU
1
;
Yun-gang TIAN
1
;
Fang-fang XIANG
1
Author Information
1. Tujia Medicine Research Center in Hunan, College of Hunan Province, Jishou University, Jishou 416000, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
Cucurbitaceae;
Hemsleya genus;
H.dolichocarpa;
cucurbitane-type triterpenoids;
anti-tumor activity
- From:
Acta Pharmaceutica Sinica
2018;53(9):1526-1531
- CountryChina
- Language:Chinese
-
Abstract:
Seven cucurbitane-type triterpenoids were isolated from the ethanol extract of the tubers of Hemsleya dolichocarpa, with a combination of various chromatographic approaches, including silica gel, Sephadex LH-20, Semi-HPLC and so on. On the basis of spectroscopic data analysis, they were identified as 3β,11α,26,27-tetrahydroxycucurbita-5,24(E)-diene-3,26-glucosides (1), scandenogenin D (2), jinfushanencin F (3), scandenoside R3 (4), scandenoside R1 (5), scandenogenin A (6), scandenoside R2 (7). Among them, compound 1 is a new triterpenoid, compound 2 showed remarkable activity against human cancer cell line HeLa with IC50 value of 6.78 μmol·L-1.
