Effects of Z-9-octadecenyl-2-propanesulfonamide on the learning and memory function of diabetes-associated cognitive decline
10.16438/j.0513-4870.2018-0344
- VernacularTitle:Z-十八碳-9-烯-丙磺酰胺对糖尿病认知功能障碍小鼠学习记忆功能的影响
- Author:
Cui-bao WANG
1
;
Ying LI
2
;
Hua-hui LU
1
;
Nan-fu WEI
1
;
Shuo HUANG
1
;
Yun WANG
1
;
Rong RAO
1
;
Shu-zhen XU
1
;
Tong REN
3
Author Information
1. Department of Anesthesiology, Xiamen Fifth Hospital, Xiamen 361000, China
2. Department of Pharmacy, Xiamen Medical College, Xiamen 361023, China
3. Medical College, Xiamen University, Xiamen 361105, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
Z-9-octadecenyl-2-propanesulfonamide;
diabetic encephalopathy;
hippocampus;
neuroprotection
- From:
Acta Pharmaceutica Sinica
2018;53(9):1504-1510
- CountryChina
- Language:Chinese
-
Abstract:
This study was designed to investigate the therapeutic effect of novel compound Z-9-octadecenyl-2-propanesulfonamide (N15) on diabetes-associated cognitive decline (DACD). Type 2 diabetes (T2DM) mice models were established with multiple injection of low doses of streptozotocin (STZ) in mice on high fat diet (HFD). Vehicle and different concentrations of N15 (50 and 100 mg·kg-1·d-1) were administrated orally for 6 weeks. The step-down test, dark avoidance task and Morris water maze were conducted at the 6th week. The level of glucose and lactic acid in hippocampus were determined and mRNA of growth associated protein-43 (GAP-43), synaptophysin (SYN), brain derived neurotrophic factor (BDNF) and neurotrophins-3 (NT-3) in hippocampus were analyzed by real time PCR. The beneficial effects of N15 on learning and memory were found in the test of step-down, dark avoidance and Morris water maze. N15 reduced the level of glucose and lactic acid in hippocampus of HFD+STZ-induced diabetic encephalopathy model mice. Additionally, the mRNA expression of GAP-43, SYN, BDNF and NT-3 in hippocampus of HFD+STZ-induced diabetic encephalopathy mice were significantly increased by N15 (P<0.01). These results suggest that the novel compound N15 can ameliorate diabetes-associated cognitive decline and the potential mechanism may be associated with the expressions of increased synaptic-related factors and neurotrophic factor in the hippocampus of diabetesassociated cognitive decline in mice.
