Exploration of “principle-recipe-composition-target-activity” association of Bupleuri Radix and Scutellariae Radix drug pair for diabetes treatment based on network pharmacology
10.16438/j.0513-4870.2018-0354
- VernacularTitle:基于网络药理学的“柴胡?黄芩”药对治疗糖尿病的“理法?方药?成分?靶标?活性”关联研究
- Author:
Hai-yan XU
1
;
Xiu-juan PENG
1
;
Yan-bin CHEN
2
;
Gang XU
2
;
Li LU
1
;
Min-na HOU
1
;
Yan-hong LIU
1
;
Feng LIU
1
;
Hai-yu XU
1
Author Information
1. Shaanxi Institute of International Trade and Commerce, Xianyang 712046, China
2. Shaanxi Buchang Pharmaceutical Co., Ltd., Xi'an 710075, China
- Publication Type:SPECIAL REPORTS
- Keywords:
network pharmacology;
Bupleuri Radix and Scutellariae Radix;
drug pair;
diabetes;
principlerecipe-composition-target-activity
- From:
Acta Pharmaceutica Sinica
2018;53(9):1414-1421
- CountryChina
- Language:Chinese
-
Abstract:
By using the integrated pharmacology platform and the big data of traditional Chinese medicine combined with the pharmacology thinking of "principle-recipe-composition-target-pathway-activity" in this study, we predicted the material basis and mechanisms of Bupleuri Radix and Scutellariae Radix drug pair for the treatment of diabetes. Fifty-nine active components were predicted, which included saponins, flavones, essential oil, fatty acids and so on. They acted on twenty-two direct targets and twenty-six main pathways respectively.The known disease targets of diabetes include arginine vasopressin receptor gene (AVP), retinoblastoma (RB1), receptor active modified protein (RAMP), platelet growth factor receptor (PDGFR), insulin receptor (INSR), α-glucosidase (GAA), etc. The pathways with diabetes effect involves endocrine system, circulatory system, digestive system, thyroid hormone signaling pathway, ErbB signaling pathway, PI3K-Akt signaling pathway, lipid metabolism and other related biological processes and metabolic pathways. The results of virtual screening in molecular docking technology indicate that flavonoids from Bupleuri Radix and Scutellariae Radix drug pair can easily form good docking mode and high affinity with peroxisome proliferators activated receptor γ (PPAR-γ) and glycogen synthase kinase-3β (GSK-3β), showing antidiabetic activity. The study provides information for the treatment of diabetes by Bupleuri Radix and Scutellariae Radix drug pair, and a new thought for the study of drug pair and complex prescription.
