Mechanism of Jiawei Foshou San on invasion and metastasis in endometriosis based on network pharmacology
10.16438/j.0513-4870.2018-0674
- VernacularTitle:基于网络药理学的加味佛手散抑制子宫内膜侵袭转移机制研究
- Author:
Ying ZHANG
1
;
Jia-hui WEI
1
;
Cheng-ling ZHANG
1
;
Pan-hong LI
1
;
Wen-wei SUN
1
;
Xiao-yu XU
1
;
Yi CHEN
1
Author Information
1. College of Pharmaceutical Sciences and Chinese Medicine, Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine, Pharmacology of Chinese Materia Medica-the Key Discipline Constructed by the State Administration of Traditional Chinese Medicine, Southwest University, Chongqing 400715, China
- Publication Type:SPECIAL REPORTS
- Keywords:
Jiawei Foshou San;
endometriosis;
network pharmacology;
invasion and metastasis;
mechanism
- From:
Acta Pharmaceutica Sinica
2018;53(9):1398-1405
- CountryChina
- Language:Chinese
-
Abstract:
Jiawei Foshou San is a new Chinese medicine compound consisting of ligustrazine, ferulic acid and fumarate. Previously Jiawei Foshou San inhibited the growth of endometriosis with unclear mechanism, especially in metastasis and invasion. In this study, network pharmacology analysis was performed to explore potential mechanism of Jiawei Foshou San on endometriosis. Jiawei Foshou San compound targets were purchase from TCMID, TCMSP and SEA database. Endometriosis targets were collected from OMIM, DisGeNET and GEO database. Networks of Jiawei Foshou San compound-compound targets and compound target-endometriosis target were established with Cytoscape 3.5.0 software. Key targets were analyzed for pathway enrichment through DAVID database. It was found that Jiawei Foshou San regulated 66 core targets (MMP2, MMP9, TIMP1, ICAM1, VEGFA, et al.) and affected 115 pathways, such as estrogen, HIF-1, TNF and GnRH signaling pathways. MMP-TIMP were uncovered as one cluster of the core targets. Furthermore, Jiawei Foshou San significantly suppressed the growth of ectopic endometrium. Meanwhile, invasion and metastasis were restrained after treating with Jiawei Foshou San through decreasing MMP-2 and MMP-9, increasing TIMP-1. In brief, these results provide a pharmacodynamic basis for the study of Jiawei Foshou San.
