Rheological properties of compound carrageenan
10.16438/j.0513-4870.2018-0445
- VernacularTitle:复配卡拉胶的流变学性质研究
- Author:
Wen-ya WANG
1
;
Bai-xue YANG
1
;
Yan-chang GONG
1
;
Bei-bei HU
1
;
Xue-li ZHAO
1
;
San-ming LI
1
Author Information
1. School of Pharmacy, Shenyang Pharmaceutical University, Benxi 117004, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
kappa carrageenan;
excipient;
compound gel;
viscosity;
rheological property
- From:
Acta Pharmaceutica Sinica
2018;53(8):1377-1382
- CountryChina
- Language:Chinese
-
Abstract:
The rheological properties of six compound gels that consists of kappa carrageenan (KC) and another excipient such as konjac gum were explored through comparison of their viscosity measured by the rotation method. The gel fluid type was dependent on the rheological curve fitted by the power-law equation. The effect of concentration on the viscosity of different compound gels was investigated by establishing the linear equation between their viscosity and concentration, the slope of which was used to determine the relation between viscosity and concentration of different compound gels. The viscous flow activation energy (Eη) was calculated by the Arrhenius equation, which was able to investigate the effect of temperature on their viscosity. The interaction between monomer and compound gels was also studied by measuring their viscosity. The results showed that six compound gels were pseudoplastic fluid. Among all compound gels, the KC-xanthan gum (KC-XG) solution exhibited the most obvious shear thinning, the strongest pseudoplasticity, while the smallest Eη, resulting in the best thermal stability of viscosity. Furthermore, the concentration of KC-sodium hyaluronate (KC-HA-Na) solution affected its viscosity significantly. The viscosity of six compound gels was greater than the summation of the two kinds of monomer gels, which suggests that there is a synergistic-viscosity interaction between KC and another excipient.
