A new polyketide from a sponge-derived fungus
10.16438/j.0513-4870.2018-0448
- VernacularTitle:海绵真菌中一个新的聚酮类化合物
- Author:
Yong-qi TIAN
1
;
Shu-ting LIN
1
;
Yong-hong LIU
2
Author Information
1. College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China
2. Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
sponge-derived fungus;
Alternaria sp. F49;
spectroscopic analysis;
secondary metabolites
- From:
Acta Pharmaceutica Sinica
2018;53(7):1134-1138
- CountryChina
- Language:Chinese
-
Abstract:
A new polyketide:3R, 5R-(-)-talaroflavone (2), along with 15 known compounds were isolated from a EtOAc extract of a sponge-derived fungus Alternaria sp. F49. Compounds 1-2 and 3-4 were separated as two pairs of enantiomers by chiral HPLC from Ⅰ and Ⅱ. The structures of compounds 1-16 were elucidated by means of NMR and MS. Furthermore, the absolute configurations of compounds 1-2 were determined by single crystal X-ray diffraction experiment and CD analyses. Compounds 6, 8-10 were isolated from this genus (Alternaria sp.) for the first time. Compound 16 showed moderate COX-2 enzyme inhibitory activity with IC50of 7.3 μmol·L-1.
