A new indole alkaloid from bulbils of Dioscorea opposite Thunb.
- VernacularTitle:零余子中一个新的吲哚类生物碱
- Author:
Wei-sheng FENG
1
;
Meng-huan GUO
1
;
Yi-ge YIN
1
;
Yan-gang CAO
1
;
Cui-lan YANG
1
;
Yang-yang WANG
1
;
Man QI
1
;
Yan-li ZHANG
1
;
Ying-jie REN
1
;
Yan-ling LIU
1
;
Xiao-ke ZHENG
1
Author Information
- Publication Type:ORIGINAL ARTICLES
- Keywords: Dioscorea L.; bulbils of Dioscorea opposite Thunb.; chemical constituent; indole alkaloid; cytotoxic activity
- From: Acta Pharmaceutica Sinica 2018;53(7):1131-1133
- CountryChina
- Language:Chinese
- Abstract: This study was designed to study the chemical constituents from bulbil of Dioscorea opposite Thunb.. Four compounds were isolated by silica gel column chromatography. On the basis of physic-chemical characters and spectroscopic data analysis, these compounds were identified as lyzalkaloid (3,4-dihydro-6-hydroxy-4-methyl-6H-pyrido[6,5-b]indol-5(1H)-one) (1), anoectochine (2), ginsenine (3), and 2-hydroxy-3-(1H-indol-3-yl) propanoic acid methyl ester (4). Compound 1 is a new indole alkaloid, named as lyzalkaloid. Compounds 2-4 were isolated from this plant for the first time. The cytotoxic activities were assessed by MTT assay. All compounds exhibited the cytotoxic activity against HepG2 and MDA-231 with IC50 values of over 100 μmol·L-1, respectively. All compounds show no significant cytotoxic activities against HepG2, MDA-231 cancer cell.
