Recent progress in targeted drug delivery nanosystems for pancreatic cancer treatment
10.16438/j.0513-4870.2018-0152
- VernacularTitle:胰腺癌靶向纳米递药系统的研究进展
- Author:
Meng-ru LI
1
;
Teng LI
1
;
Ran MO
1
Author Information
1. Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, China
- Publication Type:REVIEWS
- Keywords:
pancreatic neoplasm;
drug delivery system;
nanotechnology;
tumor targeting;
chemotherapy
- From:
Acta Pharmaceutica Sinica
2018;53(7):1090-1099
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is a highly-malignant digestive system neoplasm. The anticancer efficacies of the chemotherapeutic drugs for pancreatic cancer treatment, such as gemcitabine, are greatly limited by their poor targetability to tumor and low drug concentration in the tumor tissue. Drug delivery system plays an important role in improvement of therapeutic efficacy and reduction of adverse effects. Enhancement of the tumor targeting capacity of nanomedicine and promotion of the delivery efficiency are the key issues in the research field of pharmaceutics. In this review article, we survey recent progress in targeted drug delivery nanosystems for treatment of pancreatic cancer by targeting cancer cells, pancreatic tumor stroma, pancreatic cancer-associated cells, and pancreatic cancer stem-like cells, which will provide a new insight into clinical treatment of pancreatic cancer.
