Application of the animal model of intracerebral injection of amyloid-β oligomers to the study of Alzheimer's disease
10.16438/j.0513-4870.2018-0088
- VernacularTitle:β-淀粉样蛋白寡聚体脑内注射动物模型在阿尔茨海默病研究中的应用
- Author:
Li-sha WANG
1
;
Xin-min LIU
1
;
Xue TAO
1
;
Meng-di ZHANG
1
;
Yun-feng ZHOU
1
;
Qi CHANG
1
Author Information
1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
- Publication Type:REVIEWS
- Keywords:
Alzheimer's disease;
amyloid-β peptide;
oligomer;
intracerebral injection;
animal model
- From:
Acta Pharmaceutica Sinica
2018;53(7):1060-1067
- CountryChina
- Language:Chinese
-
Abstract:
Progressive accumulation of the amyloid-β peptide (Aβ) in the brain plays a central role in the pathogenesis of Alzheimer's disease (AD). The animal model of intracerebral injection of Aβ oligomers not only provides a method for further exploring the mechanism of Aβ in AD, but also can be used to screen drug candidates targeting Aβ oligomers. This animal model has been widely used in the study of anti-AD drugs and mechanism of AD. In this paper, we summarize the research progress in the animal model of intracerebral injection of soluble Aβ oligomers, including experimental animals, the types of Aβ, the preparation of Aβ oligomers in vitro, injection sites and doses, the duration of modeling, animal behavioral changes, and the pathological mechanisms relating to this animal model, which will contribute to the application of the animal model to various conditions.
