Research progress of SDF-1α/CXCR4 axis in the treatment of ischemic stroke with stem cells
10.16438/j.0513-4870.2017-1007
- VernacularTitle:SDF-1α/CXCR4轴在干细胞治疗缺血性脑卒中的研究进展
- Author:
Xin ZHOU
1
;
Shi-feng CHU
2
;
Jiang-fan WAN
2
;
Chen CHEN
2
;
Da-yong ZHANG
1
;
Nai-hong CHEN
2
Author Information
1. China Pharmaceutical University, Nanjing 210009, China
2. Neuroscience Center, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:REVIEWS
- Keywords:
ischemic stroke;
stem cell;
chemokine;
stromal cell-derived factor-1α;
chemokine (C-X-C motif) receptor 4
- From:
Acta Pharmaceutica Sinica
2018;53(7):1054-1059
- CountryChina
- Language:Chinese
-
Abstract:
Stroke is the leading cause of death in Chinese currently, characterized by high incidence, high morbidity and high mortality, of which ischemic stroke accounted for 87%. However, it still lacks the ideal treatment. Stem cells are a class of cells with self-renewal ability and high differentiation potential. Stem cell transplantation breaks the irreversibility of nerve injury to post-stroke infarct area. However, stem cells also requiring specific chemokines to promote their directional migration to the injured tissue site after transplanted. Stromal cell-derived factor-1α (SDF-1α) is one of the typical chemokines. SDF-1α and its specific receptor CXCR4 can induce its migration, increase its proliferation and promote angiogenesis. In this paper, the role of SDF-1α/CXCR4 axis in the treatment of ischemic stroke in stem cells is reviewed in order to provide a theoretical basis for enhancing the efficacy of stem cell transplantation in the treatment of ischemic stroke.
