Research progress of circRNA in cancer
10.16438/j.0513-4870.2018-0014
- VernacularTitle:环形RNA在癌症中的研究进展
- Author:
Sai WANG
1
;
Chen CHEN
1
;
Ying-zhe XIONG
1
;
Ling-hui XIAO
1
;
Zhao-fa LI
1
Author Information
1. Institute of Molecular Medicine, Huaqiao University, Quanzhou 362021, China
- Publication Type:REVIEWS
- Keywords:
circRNA;
miRNA sponge;
transcription;
cancer
- From:
Acta Pharmaceutica Sinica
2018;53(6):903-909
- CountryChina
- Language:Chinese
-
Abstract:
Circular RNA (circRNA) is a non-coding closed-loop single-stranded RNA molecule lacking the 5' end cap and the 3' poly (A) tail. Circular RNA is more abundant and stable than linear mRNA, and its expression is more conservative and specific. circRNA regulates cancer development through a variety of mechanisms, including miRNA sponges, regulating gene transcription, regulating RNA-binding proteins, and protein translation. This review summarizes the role of circRNA in cancer and helps to develop new clinical diagnostic techniques and treatments.
