Molecular mechanism of Shengmaiyin for arrhythmia based on integrative pharmacology
10.16438/j.0513-4870.2017-1123
- VernacularTitle:基于中药整合药理学平台的生脉饮治疗心律失常的分子机制
- Author:
Dong-mei LÜ
1
;
Ru-yi CUI
1
;
Rong-rong ZHOU
2
;
Hai-yu XU
1
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medicinal Sciences, Beijing 100700, China
2. School of Basic Medicine, Shanxi University of Chinese Medicine, Jinzhong 030600, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
Shengmaiyin;
molecular mechanism;
integrative pharmacology;
arrhythmia;
ginseng;
energy metabolism
- From:
Acta Pharmaceutica Sinica
2018;53(5):743-748
- CountryChina
- Language:Chinese
-
Abstract:
Shengmaiyin is widely used in the treatment of arrhythmia and has achieved a good effect. Due to the complexity of traditional Chinese medical formula, the pharmacological mechanism of Shengmaiyin in the treatment of arrhythmia is unclear. In this study, we used the internet-based Computation Platform (www.tcmip.cn) to explore the molecular mechanism. Shengmaiyin was found to treat the arrhythmia by modulating the pathway related to energy metabolism such as carbon metabolism, purine metabolism, carbohydrate metabolism, or by regulating the level of ATP. In this study, we find that the main active drug component in Shengmaiyin may be ginseng.
