Prenylated flavonoids from the roots of Artocarpus heterophyllus
10.16438/j.0513-4870.2017-1305
- VernacularTitle:波罗蜜根中的异戊烯基黄酮类成分
- Author:
Chuan-yun XIAO
1
;
Wen-yan LI
1
;
Xiao-xiao ZHAI
1
;
Ling-zhi ZHU
1
;
Yan-fei ZHOU
1
;
Peng-cheng YAO
1
;
Qing-xia SHU
1
;
Gang REN
1
Author Information
1. Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
Artocarpus heterophyllus;
chemical constituent;
isoprenylflavonoid;
cathepsin K
- From:
Acta Pharmaceutica Sinica
2018;53(4):592-597
- CountryChina
- Language:Chinese
-
Abstract:
Ten isoprenylated flavonoids were isolated from 95% ethanol extraction of Artocarpus heterophyllus, with a combination of various chromatographic approaches, including ODS, MCI, CHP-20 P, Sephadex LH-20 and high performance liquid chromatography. On the basis of physic-chemical characters and spectroscopic data analysis, these compounds were identified as artoheteroid E (1), cycloheterophyllin (2), artelastoxanthone (3), artoindonesianin Q (4), cudraflavone C (5), 8-(γ,γ-dimethylallyl)-5,2',4'-trihydroxy-7-methoxyflavone (6), kuwanon T (7), 6-(3-methylbut-2-enyl) apigenin (8), 5,7,2',4'-tetrahydroxy-6-(3-methylbut-3-enyl) flavone (9), albanin A (10). Among them, compound 1 is a new one, while compounds 2-4 were isolated for the first time from the plant of Artocarpus heterophyllus. All isolated compounds were screened for their inhibitory abilities against cathepsin K. Of them, compounds 3-5, 7 and 10 showed inhibitory effects with the IC50 values of 0.9, 1.6, 4.5, 24.5 and 63.5 μmol·L-1, respectively.
