Network pharmacology-based study on mechanism of liver protection of Erzhi Pill
10.16438/j.0513-4870.2017-0966
- VernacularTitle:基于网络药理学的二至丸保肝作用机制研究
- Author:
Yuan-yuan ZHAI
1
;
Qi-nan LIU
1
;
Jia XU
1
;
Wei-feng YAO
1
;
Bei-hua BAO
1
;
Yu-dan CAO
1
;
Li ZHANG
1
;
An-wei DING
1
Author Information
1. Jiangsu Key Laboratory for High Technology Research of TCM Formulae and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
network pharmacology;
Erzhi Pill;
Nvzhenzi;
Mohanlian;
protection of liver;
mechanism
- From:
Acta Pharmaceutica Sinica
2018;53(4):567-573
- CountryChina
- Language:Chinese
-
Abstract:
This study was designed to construct a "drug-core target-pathway" network of Erzhi Pill for hepatic injury treatment in an effort to explore the "multi-components, multi-targets, multi-pathways" mechanism. ADME/T calculation method was used to screen the active components of Erzhi Pill, and then predict the potential targets according to the reverse pharmacophore matching method. Biological information annotation databases (DAVID) was used to analyze the molecular function and biological process of the action targets. The Cytoscape software was used to construct the "ingredient-core target-pathway" network of Erzhi Pill for hepatic injury treatment. It was found that 39 major active ingredients of Erzhi Pill regulated 321 targets (HRAS, DCK, HSD17B1, UCK2, et al) and affected 51 pathways, such as insulin signaling pathway, FoxO signaling pathway, metabolic pathways and glycolysis/gluconeogenesis. The method revealed the action features of traditional Chinese medicine as multi-ingredients, multi-targets, multi-pathways, providing new clues for further basic study on the hepatic injury pharmacological mechanism of Erzhi Pill.
