Review and prospect on preparation technology of drug nanocrystals in the past thirty years
10.16438/j.0513-4870.2017-0920
- VernacularTitle:药物纳米晶体制备技术30年发展回顾与展望
- Author:
Peng-fei YUE
1
;
Yang LIU
1
;
Jin XIE
1
;
Ying-chong CHEN
1
;
Ming YANG
1
Author Information
1. Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, State Key Laboratory of Innovative Drug and High Efficiency and Energy Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
- Publication Type:REVIEWS
- Keywords:
nanocrystal;
preparation technology;
bottom-up;
top-down;
combinative technology
- From:
Acta Pharmaceutica Sinica
2018;53(4):529-537
- CountryChina
- Language:Chinese
-
Abstract:
Nanocrystals is a hot topic of poorly soluble drug delivery system under development. Nanocrystals is different from the nanoparticles for drug unloading in polymer materials, and nanocrystals is different from solid dispersion system, in which the drug maintains crystals state. Nanocrystals has a simple preparation process, represents an effective technology in the improvement of solubility and bioavailability of poorly soluble drugs, and has a very promising industrialization application and development potential. In this paper, we retrospect the development history of drug nanocrystals technology, review development of the preparation methods of nanocrystals, and analyze the existing problems to provide a reference to the development of drug nanocrystals preparation.
