Gene therapy and delivery strategies for ocular diseases
10.16438/j.0513-4870.2017-0890
- VernacularTitle:眼部疾病的基因治疗与递送策略
- Author:
Yan-yu ZHANG
1
;
Xin GAO
1
;
Kuan JIANG
1
;
Ling-yu TAI
1
;
Gang WEI
1
;
Wei-yue LU
1
Author Information
1. Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai 201203, China
- Publication Type:REVIEWS
- Keywords:
gene therapy;
oculardrug delivery;
viral vector;
non-viral vector;
gene editing
- From:
Acta Pharmaceutica Sinica
2018;53(4):518-528
- CountryChina
- Language:Chinese
-
Abstract:
Gene therapy has obvious advantages in the treatment of ocular diseases due to the unique structure of the eye. In recent years, there are more and more therapeutic gene-based drugs for ophthalmic application in clinical trials. Most of the delivery vectors are adeno-associated virus and administered via intraocular injection, which has potential risks. Traditional remedies, such as topical instillationor systemic administration, have limited therapeutic effects on the diseases in the posterior segment of the eye, where the chemical drugs are hard to reach. This makes the research of new strategies for gene drug delivery extremely urgent. For better understanding of the latest hot topics of ocular gene therapy, this article is prepared to introduce application of gene therapy to the typical ocular diseases and the corresponding gene-based medicines. The absorption routes for gene delivery into eyes and existing barriers are summarized. Finally, the gene delivery strategies are highlighted. The clinical application of ocular gene therapy will be boosted by overcoming the absorbing barriers and reducing the potential pitfalls.
