Research progress on regulation of signaling pathway by microRNA in phenotypic change of vascular smooth muscle cell
10.16438/j.0513-4870.2017-0991
- VernacularTitle:血管平滑肌细胞表型转化中microRNA调控信号传导通路的研究进展
- Author:
Ying CHEN
1
;
Hao-ying YU
1
;
Lan SUN
1
;
Guan-hua DU
1
Author Information
1. Beijing Key Laboratory of Drug Target Research and Drug Screening, State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:REVIEWS
- Keywords:
smooth muscle cell;
phenotype;
microRNA;
signal pathway;
vascular remodeling
- From:
Acta Pharmaceutica Sinica
2018;53(4):487-494
- CountryChina
- Language:Chinese
-
Abstract:
A change in vascular smooth muscle cell (VSMC) phenotype, known as converting from a contractile state into a synthetic phenotype, is a crucial event in vascular remodeling, which determines the occurrence, development and prognosis of cardiovascular diseases such as pulmonary hypertension and atherosclerosis. Research shows that the expression level of key signaling molecules, which controls the phenotype change of VSMC, is regulated by microRNA (miRNA), a type of non-encoding RNA. In this article, we provide a review of miRNA in the regulation of VSMC phenotype changes with a focus on the key molecules in MAPK, TGFβ/Smad and PI3K/Akt signaling pathways.
