Determination of heavy metals in Coptidis Rhizoma of different habitats and risk assessment of heavy metals under different ways of administration
10.16438/j.0513-4870.2017-0857
- VernacularTitle:不同产地黄连中重金属的含量测定及不同用药方式下黄连重金属的风险评估
- Author:
Li ZHOU
1
;
Jian YANG
1
;
Zhi-lai ZHAN
1
;
Shao-hua SHU
2
;
Sheng WANG
1
;
Ai-ping DENG
1
;
Zhong-hua MA
3
;
Lan-ping GUO
1
Author Information
1. State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
2. Medicinal Plant Institute of Huazhong Agricultural University, College of Plant Science and Technology, Wuhan 430070, China
3. Infinitus(China) Company Ltd., Guangzhou 510180, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
Coptidis Rhizoma;
heavy metal;
different administration way;
risk assessment
- From:
Acta Pharmaceutica Sinica
2018;53(3):432-438
- CountryChina
- Language:Chinese
-
Abstract:
Inductively coupled plasma mass spectrometry (ICP-MS) was applied to this study to detect heavy metal contents in Coptidis Rhizoma from different habitats, for a comprehensive understanding of heavy metal residues in Coptidis Rhizoma. Decocting method and artificial gastrointestinal digestion model were used to determine transfer rates of heavy metals in assessment of health risk of heavy metals using the target hazard quotient (THQ) developed by the US EPA (1989). The results showed that excess rates of Cu, Pb, As, Cd and Hg of 17 batches of Coptidis Rhizoma were 0, 12%, 0, 0 and 0, respectively, under the ISO international standard of Chinese medicine-Chinese herbal medicine heavy metal. The transfer rates of Cu, Pb, As, Cd and Hg were 3.63%, 1.69%, 37.17%, 20.86% and 0 in decoction solution, respectively, and 59.15%, 29.98%, 67.55%, 104.59% and 0 in artificial gastrointestinal solution, respectively. The values of THQ under the two ways of administration in adults and children were 0.001 0, 0.005 3 and 0.000 7, 0.003 6, respectively, and the maximum residue limits (MRL) of heavy metals in Coptidis Rhizoma were higher than the contents of samples in this study. The research showed that the contents of heavy metals in Coptidis Rhizoma were in the safe ranges with no obvious risks to human body, indicating that the excessive of heavy metals in Coptidis Rhizoma might be attributed to the unduly strict standard. The contents of heavy metals in Coptidis Rhizoma of different habitats was estimated for health risks using international risk assessment model, which provides a reference for establishment of heavy metal standards in Coptidis Rhizoma.
