Pharmacokinetic of Jiaotai pill in normal and depressed rats
10.16438/j.0513-4870.2017-0854
- VernacularTitle:交泰丸在正常大鼠及抑郁大鼠体内的药代动力学比较研究
- Author:
Li-jing ZHU
1
;
Yong-tao BAI
1
;
Wei-dong ZHANG
1
;
Wen JING
1
;
Qian ZHANG
1
;
Wen-zheng JÜ
1
;
Guo-liang DAI
1
Author Information
1. Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
Jiaotai pill;
chronic unpredictable mild stress model;
alkaloid;
pharmacokinetics
- From:
Acta Pharmaceutica Sinica
2018;53(3):425-431
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to explore the pharmacokinetics of epiberberine, jatrorrhizine, coptisine, palmatine, berberine of Jiaotai pill in the normal and depressed rats. According to ‘Katz’ method, the model of chronic unpredictable mild stress (CUMS) was established. The extract of Jiaotai pill was orally administered to rats, and the blood samples were collected via the the oculi chorioideae vein according to the time schedule. The concentrations of epiberberine, jatrorrhizine, coptisine, palmatine, berberine in rat plasma were determined by LC-MS/MS, and the pharmacokinetic parameters were calculated by DAS1.0 software. Compared with normal rats, the Cmax of palmatine, coptisine, berberine and jatrorrhizine in Jiaotai pill in depressed rats were 1.99, 2.14, 2.3, 1.82 times than the normal group, while the AUC0−t were 1.23, 1.25, 1.29, 1.46 times and the AUC0−∞ were 1.21, 1.25, 1.30, 1.43 times, which were significantly different.
