Short term high-fat diet feeding alleviates the cognitive impairment induced by okada acid injection in rats
10.16438/j.0513-4870.2017-1009
- VernacularTitle:短期高脂饮食缓解冈田酸诱导的大鼠认知功能损伤
- Author:
Tian-bi ZHU
1
;
Zhao ZHANG
2
;
Piao LUO
1
;
Shi-feng CHU
2
;
Nai-hong CHEN
1
Author Information
1. College of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, China
2. Neuroscience Center, Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100050, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
Alzheimer's disease;
okada acid;
high fat diet;
neuroprotection;
inflammasome
- From:
Acta Pharmaceutica Sinica
2018;53(3):383-387
- CountryChina
- Language:Chinese
-
Abstract:
This study was designed to test the effect of short-term high-fat diet feeding on the cognitive impairment in a rat model of Alzheimer's disease. After establishment of Alzheimer's disease model, the rats were fed on a high-fat diet, and subjected to water maze (Morris water maze, MWM) behavioral test for learning and memory ability. Western blot was used to detect the expression of caspase-1 pathway. The results showed that short-term high-fat diet could alleviate the damage of okada acid in Morris water maze. The mechanism may be mediated by the regulation of the NLRP3/caspase-1 signaling pathway, which alleviates neuronal damage, resulting in a protective effect.
