Research situation of pH low insertion peptides

VernacularTitle:低pH插入肽研究概况
Author: Xue-li JIA ¹ ; Jia ZHANG ¹ ; Ting ZHAO ¹ ; Qing DU ¹ ; De-ying CAO ¹ ; Bai XIANG ¹ ; Ge-xia GENG ² ; Xian-rong QI ³
Author Information

1. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
2. Hebei Center For Food And Drug Evaluation and Certification, Shijiazhuang 050091, China
3. School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
Publication Type:REVIEWS
Keywords: pH low insertion peptide; extracellular acidic environment; theranostic; tumor; nano-sized carrier
From: Acta Pharmaceutica Sinica 2018;53(3):375-382
CountryChina
Language:Chinese
Abstract: Extracellular acidity has been associated with many pathological states, such as cancer, ischemic stroke, neurotrauma and infection, which makes it an effective target for therapy and diagnosis of such diseases. As a polypeptide vector, pH low insertion peptides (pHLIPs) are endowed with high sensitivity to extracellular acidic environment, which can insert the membrane and deliver payload to pathological cells in a pH dependent manner. Here, theranostic applications of pHLIP in disease, are reviewed in two aspects:pHLIP-mediated single-molecule transporter and nano-sized carrier.