Progress on AIDS drug targets and small molecule inhibitors
10.16438/j.0513-4870.2017-1176
- VernacularTitle:抗艾滋病药物新靶标及其小分子抑制剂的研究进展
- Author:
Zhi-peng HUO
1
;
Xiao-fang ZUO
1
;
Dong-wei KANG
1
;
Peng ZHAN
1
;
Xin-yong LIU
1
Author Information
1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
- Publication Type:REVIEWS
- Keywords:
AIDS;
drug target;
HIV-1;
replication cycle;
small molecule inhibitor;
drug design
- From:
Acta Pharmaceutica Sinica
2018;53(3):356-374
- CountryChina
- Language:Chinese
-
Abstract:
The difficulty to eradicate the HIV-1, off-target effects together with the rapid emergence of multidrug-resistant strains have created an urgent need for more potent and less toxic therapies against other targets of HIV virus. From the point of view of medicinal chemistry, we summarizes and discusses current endeavours towards the discovery and development of novel inhibitors with various scaffolds or distinct mechanisms of action, and also provides examples illustrating new methodologies in medicinal chemistry that contribute to the identification of novel antiretroviral agents.
