The progress of multifunctional envelope-type nano device
10.16438/j.0513-4870.2017-0724
- VernacularTitle:多功能信封型纳米系统的研究进展
- Author:
Li-ping YANG
1
;
Li CAO
2
;
Ting ZHAO
1
;
Qing DU
1
;
De-ying CAO
1
;
Bai XIANG
1
;
Jun-xia XIE
3
Author Information
1. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
2. Department of Pharmacy, Hebei General Hospital, Shijiazhuang 050051, China
3. Department of Pharmaceutical, Hebei Chemical and pharmaceutical College, Shijiazhuang 050026, China
- Publication Type:REVIEWS
- Keywords:
multifunctional envelope-type nano device;
gene vector;
siRNA;
DNA;
peptides
- From:
Acta Pharmaceutica Sinica
2018;53(1):47-53
- CountryChina
- Language:Chinese
-
Abstract:
The key of gene therapy is to deliver the functional gene to the target tissue in the body. The safe and efficient gene carrier is particularly important in the targeted delivery. Multifunctional envelope-type nano device (MEND), based on concept "Programmed packaging", is a new type of gene carrier system, with high encapsulation efficiency, favourable stability, high transfection efficiency, easy preparation, etc. MEND is designed to control intracellular trafficking as well as the tissue distribution of encapsulated compounds such as nucleic acids/proteins/peptides, permitting them to function at the appropriate location. In this paper, research progresses in MEND are reviewed in accordance with three types of payloads:the small interfering RNA (siRNA), DNA and proteins/peptides in recent years.
