Advances in the study of New Delhi metallo-β-lactamase 1
10.16438/j.0513-4870.2017-0915
- VernacularTitle:新德里金属β-内酰胺酶NDM-1的研究进展
- Author:
Yu-ru MA
1
;
Hong-xia ZHAO
1
;
Qing-zhi GAO
1
Author Information
1. School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
- Publication Type:REVIEWS
- Keywords:
superbug;
NDM-1;
inhibitor;
metallo-β-lactamase
- From:
Acta Pharmaceutica Sinica
2018;53(1):28-36
- CountryChina
- Language:Chinese
-
Abstract:
The New Delhi metallo-β-lactamase-1 (NDM-1) was first reported in 2010, detected in a Klebsiella pneumoniae isolate from a Swedish patient of Indian origin. It has recently attracted extensive attention for its biological activities to catalyze the hydrolysis of almost all of β-lactam antibiotics. The gene for NDM-1 can spread from one strain of bacteria to another by horizontal gene transfer. The most troubling aspect is that there are currently no clinically available inhibitors to block the metallo-β-lactamase action. Therefore, there is urgent need to develop new NDM-1 inhibitors, which can protect β-lactam antibiotics from the hydrolysis effect of NDM-1. In this review, the current research, drug-assistant mechanism and potential NDM-1 inhibitors are summarized.
