Advances in study of pharmacological effects of ginsenoside Rg1 in hepatic diseases
10.16438/j.0513-4870.2017-0578
- VernacularTitle:人参皂苷Rg1在肝脏疾病中的药理作用研究进展
- Author:
Piao LUO
1
;
Shi-feng CHU
1
;
Yan GAO
2
;
Lin-ming LUO
1
;
Lan PENG
1
;
Nai-hong CHEN
1
Author Information
1. College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China
2. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:REVIEWS
- Keywords:
liver injury;
ginsenoside Rg1;
oxidative stress;
anti-inflammatory;
anti-apoptosis
- From:
Acta Pharmaceutica Sinica
2018;53(1):21-27
- CountryChina
- Language:Chinese
-
Abstract:
Ginsenoside Rg1 is one of the main active components of ginseng with various pharmacological activities including anti-inflammatory, anti-oxidation, anti-aging, anti-tumor and anti-apoptosis. Ginsenoside Rg1 plays a protective role in multiple tissues and organs, which shows the multiple targeting properties of the pharmacological effects. Recently, a number of studies have demonstrated that ginsenoside Rg1 has a protective role in the liver due to its multiple pharmacological effects. In chemical liver injury models, or in other liver injury models, ginsenoside Rg1 can alleviate liver necrosis induced by oxidative stress and inflam-mation. This article provides a review of the recent studies on the efficacy of ginsenoside Rg1 in the treatment of various liver damage and the molecular mechanism.
