Identification of chemical constituents of Yuanhu Zhitong prescription by HPLC-QTOF/MS
10.16438/j.0513-4870.2016-0594
- VernacularTitle:HPLC-QTOF/MS方法分析元胡止痛方的化学成分
- Author:
Yan-qi HAN
1
;
Jun XU
1
;
Su-xiao GONG
1
;
Tie-jun ZHANG
1
;
Chang-xiao LIU
2
Author Information
1. Tianjin Engineering Laboratory of Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin, 300193, China
2. Tianjin Center for New Drug Evaluation and Research, State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300193, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
Yuanhu Zhitong prescription;
HPLC-QTOF/MS;
chemical constituent;
qualitative analysis
- From:
Acta Pharmaceutica Sinica
2017;52(1):132-138
- CountryChina
- Language:Chinese
-
Abstract:
This study was designed to clarify the chemical constituents in Yuanhu Zhitong prescription (YHZT), a rapid high performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry (HPLC-QTOF/MS) method was established. Based on the high resolution MS spectra data, fragmentation ion information, reference standards data and literature reports, 51 peaks including 28 alkaloid compounds and 23 coumarin compounds were identified. The chemical constituents in YHZT were rapidly, accurately, systematically analyzed. The results lay a foundation for the quality control of effective compounds of YHZT.
