The prospects of ferroptosis in the pathogenesis of liver disease
10.16438/j.0513-4870.2017-0336
- VernacularTitle:新型细胞死亡方式ferroptosis在肝疾病机制中的研究前景
- Author:
Hong-min YU
1
;
Min WANG
2
;
Zhong-fu MAO
1
;
Fang-xuan HAN
2
;
Yi-fang LI
1
;
Hiroshi KURIHARA
1
;
Rong-rong HE
1
Author Information
1. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China
2. Department of Pharmacy, Hainan General Hospital, Haikou 570311, China
- Publication Type:REVIEWS
- Keywords:
ferroptosis;
reactive oxygen species;
lipid peroxidation;
liver diseases
- From:
Acta Pharmaceutica Sinica
2017;52(12):1783-1790
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a novel type of cell death which induced by iron-dependent lipid peroxidation accumulation. This type of cell death is significantly different from other cell death in terms of morphology, genetics and biochemistry. It has been reported that ferroptosis is involved in a variety of human diseases, particularly in liver diseases. Therefore, screening and studying of inhibitors or activators of ferroptosis may provide novel strategies for prevention and treatment of liver diseases. This review provides the biological characteristics and regulatory signaling pathways of ferroptosis, as well as the relationship between ferroptosis and liver diseases, which will contribute to new insight into the pathogenesis of liver diseases.
