Preliminary study of antiemetic components in Euodia rutaecarpa based on spectrum-effect correlation analysis
10.16438/j.0513-4870.2017-0546
- VernacularTitle:基于谱-效相关分析的吴茱萸止呕药效物质的初步研究
- Author:
Yang CHEN
1
;
Jian LIANG
2
;
Wei DONG
1
;
Fei LI
1
;
Jia-hao DONG
1
;
Lan CAO
2
;
Jin-bin YUAN
1
Author Information
1. Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
2. Research Center for the Resourcing of Traditional Chinese Medicine and Minority Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
Euodia rutaecarpa;
antiemetic effect;
UHPLC-Q-TOF/MS;
orthogonal partial least squares;
spectrum-effect relationship
- From:
Acta Pharmaceutica Sinica
2017;52(11):1737-1742
- CountryChina
- Language:Chinese
-
Abstract:
This study was designed to screen the antiemetic components of Euodia rutaecarpa, and elucidate its material basis on the spectrum-effect correlation analysis. The UHPLC-Q-TOF/MS (UHPLC-quadrupole time-of-flight mass spectrometry) technology was used to obtain the fingerprint of Euodia rutaecarpa extracts. The perfusion of copper sulfate was used as a model to study the antiemetic effect by vomiting. The orthogonal partial least squares (OPLS) method was used to analyze the spectrum-effect relationship. The results indicated the following compounds were the potential antiemetic components such as rutin, limonin, narcissoside, chrysoeriol-7-O-rutinoside, hyperoside, isorhamnetin-3-O-β-D-galactoside, 1-methyl-2-undecyl-4(1H)-quinolone, 1-methyl-2-[(Z)-4-nonenyl]-4(1H)-quinolone. This study provides the experimental basis in use of Euodia rutaecarpa in the future, and provides the research methods and ideas for the similar study on the pharmacodynamic material basis of traditional Chinese medicine.
