A new triterpenoid from roots of Psidium guajava
10.16438/j.0513-4870.2017-0565
- VernacularTitle:番石榴根中一个新的三萜类成分
- Author:
Cai-ying PENG
1
;
Ying-zheng HUANG
1
;
Jian-qun LIU
1
;
Hui-lian HUANG
1
;
Ji-cheng SHU
1
Author Information
1. Key Laboratory of Modern Preparation of Traditional Chinese Medicines, Ministry of Education, Jiangxi University of Traditional Chinese Medicines, Nanchang 330004, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
Psidium guajava;
chemical constituent;
ursane;
triterpenoid;
cytotoxic activity
- From:
Acta Pharmaceutica Sinica
2017;52(11):1731-1736
- CountryChina
- Language:Chinese
-
Abstract:
To investigated the chemical constituents of the roots of Psidium guajava,we isolated seven compounds by silica gel column chromatography.These include oleanane derivatives,2 α,3β,6β,23-tetrahydroxylurs-12,20(30)-dien-28-oic acid β-D-glucopyranoside (1),2α,3β,6β,23-tetrahydroxylurs-12,18-dien-28-oic acid β-D-glucopyranoside (2),2α,3β,23-trihydroxylurs-12,18-dien-28-oic acid β-D-glucopyranoside (3), nigaichigoside F1(4),asiaticoside C (5),2α,3β,6β,19α,23-pentahydroxylurs-12,18-dien-28-oic acid β-Dglucopyranoside (6) and 2α,3β,19α,23-tetrahydroxylurs-12-en-28-oic acid (7).Their structures were elucidated on the basis of spectral analysis with reference to the published data.Compound 1 is brand new,compounds 2-6 were first isolated from this plant.The new compound was evaluated for their cytotoxic activity against human hepatoma Bel 7402 in vitro.The results were expressed as the ratio of inhibiting Bel 7402 cells growth by comparing to untreated cells.The new compound (concentration:25 μmol·L-1) showed the ratio values of 52.5%.
