Research progress of the exosomes as drug delivery vehicles of Chinese herbal drugs
10.16438/j.0513-4870.2017-0547
- VernacularTitle:外泌体作为中药载体的研究进展
- Author:
Peng YUAN
1
;
Xiao-chen GUO
2
;
Jun-ping ZHANG
2
;
Shi-chao LÜ
2
;
Ya-ping ZHU
2
Author Information
1. Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
2. The First Affiliated Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
- Publication Type:REVIEWS
- Keywords:
exosome;
drug carrier;
Chinese herbal drug;
nanotechnology;
targeting;
bioavailability;
water-insoluble drug
- From:
Acta Pharmaceutica Sinica
2017;52(11):1667-1672
- CountryChina
- Language:Chinese
-
Abstract:
As a new carrier of intercellular information, the exosomes is widely regarded as a natural drug carrier for its extensive distribution, non-immunity and targeting in human body. Chinese herbal drugs act at multiple targets and through different pathways in the prevention and treatment of diseases, but the preparation is relatively simple, there is a low solubility in the effective ingredients and low bioavailability, which limit the efficacy of the medicine. Using the new drug delivery approach of the exosomes, it is better to deliver the effective components to target cells. In this review, we reviewed the biological characteristics of exosomes and its application as a carrier of Chinese herbal drugs.
