Recent progress of inhibitors targeting HIV-1 NCp7

VernacularTitle:HIV-1核壳体蛋白NCp7抑制剂研究新进展
Author: Hai-yong JIA ¹ ; Ji YU ¹ ; Xin-hao LIU ¹ ; Jian ZHANG ¹ ; Peng ZHAN ¹ ; Xin-yong LIU ¹
Author Information

1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmacy, Shandong University, Jinan 250012, China
Publication Type:REVIEWS
Keywords: AIDS; HIV-1; NCp7; inhibitor; drug design
From: Acta Pharmaceutica Sinica 2017;52(11):1652-1659
CountryChina
Language:Chinese
Abstract: The acquired immunodeficiency syndrome (AIDS) is a serious infectious disease infected by human immunodeficiency virus type 1 (HIV-1). HIV-1 nucleocapsid protein 7 (HIV-1 NCp7) plays an important role in the progress of virus reverse transcription and integration. Thus, the central role and conservative nature of the NCp7 protein make it an attractive target for development of novel anti-HIV agents. This review summarizes the research progress of HIV-1 NCp7 inhibitors in the past decade.