Research advances in brain monoamine neurotransmitters in the aging-associated memory decline
10.16438/j.0513-4870.2017-0471
- VernacularTitle:衰老性学习记忆减退相关的脑内单胺类神经递质研究进展
- Author:
Jia-qi LI
1
;
Li GAO
1
;
Yu-zhi ZHOU
1
;
Xue-mei QIN
1
;
Guan-hua DU
2
Author Information
1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
2. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:REVIEWS
- Keywords:
aging;
learning and memory;
monoamine neurotransmiter;
synaptic plasticity;
long-term potentiation
- From:
Acta Pharmaceutica Sinica
2017;52(11):1639-1646
- CountryChina
- Language:Chinese
-
Abstract:
Learning and memory decline is an important manifestation of aging, seriously affecting the health and life quality of the elderly. Aging-related learning and memory decline is often accompanied by decreased levels of norepinephrine, dopamine and serotonin neurotransmitters in the relevant brain regions. Monoamine neurotransmitters in different brain regions bind to receptors and regulate synaptic plasticity, which play an important role in learning and memory. This article reviews the changes of monoamine neurotransmitters in different brain regions, the mechanisms in regulation of learning and memory, and the factors causing abnormal levels of neurotransmitters in the process of aging in order to better understand the mechanisms of senile learning and memory decline to facilitate drug research.
