Optimization and evaluation of intermediate uniformity in Chinese medicine pill powders based on particle design principle:exemplifying by Xiaojin Pills
10.16438/j.0513-4870.2017-0495
- VernacularTitle:基于粒子设计原理的中药制丸粉末中间体均一性优化与评价:以小金丸为例
- Author:
Xi XIONG
1
;
Xiao-ping WANG
1
;
Ding-kun ZHANG
1
;
Gui-lin REN
1
;
Zhi-ping GUO
2
;
Ming YANG
3
;
Qing-chu TAN
1
;
Li HAN
1
Author Information
1. Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources Co-founded by Sichuan Province and Ministry of Science and Technology, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
2. Sichuan Houde Medical Technology Co., Ltd., Chengdu 610041, China
3. Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
Xiaojin Pill;
particle design;
powder science;
LC-MS/MS;
GC;
homogeneity evaluation
- From:
Acta Pharmaceutica Sinica
2017;52(10):1611-1620
- CountryChina
- Language:Chinese
-
Abstract:
Based on the principle of particle design, the powder of Xiaojin Pills was prepared, and the quality uniformity was investigated by means of powder characterizations and content uniformity. By studying the mixed crushing rules of the classified materials and the design principle of the powder particles of Chinese medicine, the powder of the Xiaojin Pills was prepared. At the same time, the manmade mixed powder and the control powder prepared by pharmacopoeia were prepared. The mixed homogeneity of the three powders was evaluated by particle size distribution and color difference. The GC-MS and LC-MS/MS were used to study the homogeneity of their contents. The best preparation process of particle design powder is:materials easily crushed are smashed for 50 min in the vibrating ultrafine mill with -15℃, then add the materials difficultly crushed into the mill and let them crushed together for 3 min. The particle size range of manmade mixed powder was the largest with the particle size difference being more than 100 microns, the RSD value being 26.07%. The particle size range was more than 50 microns in the powder prepared by pharmacopoeia, and the RSD was nearly 15%. The difference in particle size was only around 4 μm and the RSD value was 3.18%. The color difference test showed that the composite chromatism (dE*) value of the powder prepared by pharmacopoeia was the largest for the RSD was 84.56%. The RSD of manmade mixed powder and the powder prepared by Pharmacopeia were 53.83% and 32.83%, respectively. The RSD value of the particle designed powder's muscone content is about 50% of the other two kinds of powders. The contents of 10 components in powders were determined by LC-MS/MS. The RSD values of the particle designed powder were much smaller than other two kinds of powders. Results indicate that the uniformity of the particle designed powder is better than other two kinds of powders. Chinese medicine particle design technology can effectively improve the uniformity of traditional Chinese medicine powder.
