Identification of polygala oligosaccharide esters and their metabolites in rat plasma after oral administration of ethanol extract of Kai Xin San by UHPLC-MS

VernacularTitle:UHPLC-MS法鉴定大鼠灌服开心散后血中远志糖酯类化合物及其代谢产物
Author: Na WANG ¹ ; AHMAD HASSAN ¹ ; Yong-ming JIA ¹ ; Di XUE ¹ ; CHAULAGAIN RAM ¹ ; Shu-ming HUANG ² ; Xue-wei LIU ¹
Author Information

1. Qiqihar Medical University, Qiqihar 161006, China
2. Heilongjiang University of Chinese Medicine, Harbin 150040, China
Publication Type:ORIGINAL ARTICLES
Keywords: Kai Xin San; blood transitional component; polygala oligosaccharide ester; metabolite
From: Acta Pharmaceutica Sinica 2017;52(10):1592-1598
CountryChina
Language:Chinese
Abstract: Using a UHPLC-TOF/MS method combined with software of Masslynx V4.1 and database in the literatures, a total of 20 polygala oligosaccharide esters (POEs) were identified in 60% ethanol extract of Kai Xin San (KXS-60%E). Furthermore, 14 POEs as well as 4 POE-metabolites were identified in rat plasma. The results revealed that POEs and POE-metabolites which were identified in rat plasma, were key components in KXS-60%E and the potential bioactive compounds for KXS action in the treatment of AD.