Recent progress in synthesis and pharmacological effects of ellipticine and its derivatives
10.16438/j.0513-4870.2017-0230
- VernacularTitle:抗肿瘤药玫瑰树碱及其衍生物的合成和药理研究进展
- Author:
Jing-jing LIN
1
;
Ya-jun YANG
1
;
Long-ying SHEN
1
;
Xian-dao PAN
1
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:REVIEWS
- Keywords:
ellipticine;
synthesis;
derivatives;
antitumor activity;
mechanism of action;
structure-activity relationship
- From:
Acta Pharmaceutica Sinica
2017;52(9):1387-1396
- CountryChina
- Language:Chinese
-
Abstract:
Ellipticine is an alkaloid isolated from natural product with cytotoxicity, which has antitumor and anti-aids activity. Since it was first identified in 1959, a great deal of effort has been devoted to the development of various approaches for synthesis of ellipticine. This review provides a summary for synthesis approaches of ellipticine from different starting materials. The antitumor mechanism and structure-activity relationship are also discussed.
