Analysis of the effect of moisture adsorption on the compressibility of extracts of Puerariae Lobatae Radix by dynamic vapor sorption
10.16438/j.0513-4870.2017-0260
- VernacularTitle:应用动态水蒸汽吸附法分析葛根提取物的吸湿性对其压缩成形性的影响
- Author:
Li-jie ZHAO
1
;
Xiao LIN
1
;
You-jie WANG
1
;
Ruo-fei DU
1
;
Yi FENG
1
Author Information
1. Engineering Research Center of Modern Preparation Technology of TCM, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
moisture adsorption;
dynamic water vapor adsorption;
enthalpy-entropy compensation;
tensile strength;
elastic recovery
- From:
Acta Pharmaceutica Sinica
2017;52(8):1318-1323
- CountryChina
- Language:Chinese
-
Abstract:
With the extracts of Puerariae Lobatae Radix as the research object, the moisture absorption isotherm at 298, 308 and 318 K was determined through dynamic water vapor adsorption. Moisture absorption isotherm models were applied to the simulation of moisture absorption behavior. The enthalpy, entropy and Gibbs free energy for moisture adsorption were calculated according to the model and the enthalpy-entropy compensation was used to analysis moisture adsorption process. It was shown that the adsorption isotherm coincided with GAB model or Ferro-Fontan model. Moisture absorption process was an exothermic process which was driven by entropy. The effect of moisture on compressibility was evaluated through tensile strength and elastic recovery with water content, pressure force and speed variation. It was supposed that right amount of moisture was required to compression and compaction.
