Comparative pharmacokinetic study of vonoprazan in acute hepatic injury rats and normal rats

VernacularTitle:沃诺拉赞在急性肝损伤模型大鼠与正常大鼠体内药代动力学比较研究
Author: Shi-yin GU ¹ ; Yun-xi ZHONG ¹ ; Ying PENG ¹ ; Xiao-liang JIN ¹ ; Qing-qing CHANG ¹ ; Guang-ji WANG ¹ ; Jian-guo SUN ¹
Author Information

1. Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China
Publication Type:ORIGINAL ARTICLES
Keywords: acute hepatic injury; vonoprazan; CCl₄; pharmacokinetics
From: Acta Pharmaceutica Sinica 2017;52(8):1276-1281
CountryChina
Language:Chinese
Abstract: Hepatic disease is one of the high-prevalence diseases in China, of which gastrointestinal bleeding is a common complication treated by proton pump inhibitors. Vonoprazan is a novel proton pump inhibitor which acts better than lansoprazole in pharmacokinetics and pharmacodynamics. In this study, the pharmacokinetics of vonoprazan was compared between acute hepatic injury and normal condition in rats. Results showed that the exposure (AUC) of vonoprazan was significantly higher in rats with acute hepatic injury than in normal rats, and the metabolites formation rates of vonoprazan also slowed down, which might be due to the change of activity of enzymes and transporters. This find may provide a theoretical basis for the dose regulation of vonoprazan in patients with hepatic injury.