Network pharmacology-based study on intervention mechanism of Huanglian Jiedu decoction in the treatment of Alzheimer's disease
10.16438/j.0513-4870.2017-0144
- VernacularTitle:基于网络药理学的黄连解毒汤治疗阿尔兹海默症的作用机制研究
- Author:
Li-min SUN
1
;
Li-fang LIU
1
;
Hua-xu ZHU
2
;
Bao-jie ZHU
2
;
Qi-chun ZHANG
2
Author Information
1. The State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
2. Jiangsu Collaboration Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
network pharmacology;
Huanglian Jiedu decoction;
Alzheimer's disease;
mechanism;
molecular docking
- From:
Acta Pharmaceutica Sinica
2017;52(8):1268-1275
- CountryChina
- Language:Chinese
-
Abstract:
This study was designed to explore the "multi-components, multi-targets and multi-pathways" intervention mechanism of Huanglian Jiedu decoction (HLJDD) in the treatment of Alzheimer's disease (AD) by pharmacological network technology, which may establish a foundation for drug development and innovative research. Seventeen active constituents of HLJDD with anti-AD activities were submitted to PharmMapper and Molecule Annotation System (MAS 3.0) bioinformatics softwares to predict the target proteins and carry out related KEGG pathways annotation respectively. The network of "active compound-target-pathway" was constructed and analyzed using the Cytoscape 3.4.0 software. The results suggest that 47 pathways are affected by the 17 active components through 59 target proteins, in which 4 target proteins are related to AD and 2 pathways related to neuroinflammation, respectively. The effect of HLJDD on AD may be dependent on clearing/reducing β-amyloid protein, inhibiting Tau hyperphosphorylation, anti-inflammation and immunoregulation.
