The application of poly (2-ethyl-2-oxazoline) in drug delivery system
10.16438/j.0513-4870.2017-0142
- VernacularTitle:聚(2-乙基-2-噁唑啉)在药物递送系统中的应用
- Author:
Juan MAO
1
;
Jian-ming LI
1
;
Jin-song DING
1
Author Information
1. School of Xiangya Pharmaceutical Sciences, Central South University, Changsha 410013, China
- Publication Type:REVIEWS
- Keywords:
poly(2-ethyl-2-oxazoline);
polyethylene glycol;
pH-sensitive;
thermosensitive;
drug delivery system
- From:
Acta Pharmaceutica Sinica
2017;52(8):1235-1240
- CountryChina
- Language:Chinese
-
Abstract:
Poly(2-ethyl-2-oxazoline) (PEOz), a hydrophilic long-chain polymer synthesized by living cationic ring-opening isomerization polymerization of 2-ethyl-2-oxazoline, has the characteristics of low toxicity, biocompatibility, flexible chain, and modified expediently. PEOz is a potential substitute of polyethylene glycol (PEG) to render the ability of long-circulation, enhance cellular uptake and endosomal escape behaviors to PEOz modified drug delivery system. In this review, we summarized recent literature for the research progress of physicochemical properties, synthetic methods and the application of PEOz in drug delivery system.
