Comparision and analysis on the blood concentration of common Chinese medicine and Western medicine
10.16438/j.0513-4870.2017-0285
- VernacularTitle:临床常用中西药血药浓度的比较与分析
- Author:
Jing-jing XU
1
;
Ming-ying SHANG
1
;
Feng XU
1
;
Yao-li LI
1
;
Guang-xue LIU
1
;
Xuan WANG
2
;
Shao-qing CAI
1
Author Information
1. Department of Natrual Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
2. Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
- Publication Type:REVIEWS
- Keywords:
blood concentration;
Western medicine;
Chinese medicine;
pharmacodynamical material basis;
pharmacological mechanism
- From:
Acta Pharmaceutica Sinica
2017;52(8):1222-1234
- CountryChina
- Language:Chinese
-
Abstract:
To a certain extent, the drug effect is determined by its blood concentration. It is generally accepted that the blood concentrations of constituents of Chinese medicines are very low. There is no sufficient experimental bases and references on its degree and the possibility of taking effect. In this study, 69 papers were collected and analyzed by searching the database of Scifinder, Pubmed, CNKI. The minimum effective blood concentrations of 73 common Western medicines and the maximum blood concentrations of 211 in vivo constituents of 40 Chinese medicines (single herb or compound Chinese medicine) were summarized. It was found that the maximum blood concentrations of the most in vivo constituents of Chinese medicines were much less than the minimum effective blood concentrations of the Western medicines. Specifically, the minimum effective blood concentrations of 17 Western medicines (23% of total) and the maximum blood concentrations of the 143 in vivo constituents of Chinese medicines (68% of total) were less than 100 ng ·mL-1; the minimum effective blood concentrations of 31 Western medicines (42% of total) and the maximum blood concentrations of the 20 in vivo constituents of Chinese medicines (9% of total) were more than 1 000 ng·mL-1. In this paper, a systematic summary and comparison of the blood concentrations in traditional Chinese medicines and Western medicines were conducted, which could provide a new ideas and references for the study of the pharmacodynamical material basis and its mechanism in traditional Chinese medicine.
