Application of expression quantitative trait loci analysis in pharmacogenomics
10.16438/j.0513-4870.2017-0037
- VernacularTitle:表达数量性状位点分析在药物基因组学中的应用
- Author:
Zhang-ren CHEN
1
;
Fa-zhong HE
1
;
Mou-ze LIU
1
;
Hong-hao ZHOU
1
;
Wei ZHANG
1
Author Information
1. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
- Publication Type:REVIEWS
- Keywords:
expression quantitative trait loci;
pharmacogenomics;
single nucleotide polymorphism;
transcriptional level
- From:
Acta Pharmaceutica Sinica
2017;52(8):1203-1208
- CountryChina
- Language:Chinese
-
Abstract:
In the era of genome-wide association study (GWAS), a large number of drug response-related loci have been identified in the non-coding sequences. The interpretation of these loci in mechanism is concerned with the effects on the mRNA expression level of these genes. Expression quantitative trait loci (eQTL) studies indicate the relationship of genome variants and the level of mRNA. Its elucidation of the relationship between genetic variation and gene expression, gene interaction and gene regulatory network provides an efficacious mean for pharmacogenomics. The effects of gene polymorphism on drug responses have been unraveled thoroughly in studies which combined pharmacogenomics with eQTL and GWAS.
