Synthesis of functional phospholipids and preparation of shear-stress sensitive liposomes
10.16438/j.0513-4870.2017-0136
- VernacularTitle:功能性磷脂的合成及剪切力敏感型脂质体的制备
- Author:
Qin KE
1
;
Ping-yuan WANG
2
;
Yun-qiu MIAO
2
;
Jin-ying LIANG
2
;
Shu-fang HE
2
;
Xin-xin ZHANG
2
;
Yong GAN
2
Author Information
1. School of Pharmaceutical Sciences, Nanchang University, Nanchang 330006, China
2. Shanghai Institute of Material Medica, Chinese Academy of Sciences, Shanghai 201203, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
liposome;
thrombosis;
sensitivity;
fluorescent dye;
specificity
- From:
Acta Pharmaceutica Sinica
2017;52(7):1178-1185
- CountryChina
- Language:Chinese
-
Abstract:
This study aims to synthesize new phospholipids, 1,3-dipalmaminophospholipid(Pad-PC-Pad), and prepare shear-stress sensitive liposomes(SSSL). 1H NMR and MS indicated that Pad-PC-Pad were fully synthesized successfully. SSSL were prepared by filming-rehydration method with Pad-PC-Pad, which loaded calcein with aggregation-caused quenching(ACQ)characteristics to evaluate shear-stress sensitivity of liposomes and release behavior of liposomes in vitro. The results showed that the particle size of liposomes was 106.91 ± 1.24 nm and liposomes had lenticular morphology under transmission electron microscope. The release of calcein was increased with ultrasonic power, which suggests that the liposomes is shear-stress sensitive. Moreover, the liposomes exhibited a releasing effect for obstructed region under high shear-stress in a model system. Therefore, we synthesized quick functional phospholipid Pad-PC-Pad and the liposomes made from Pad-PC-Pad was shear-stress sensitive, which may be used for treatment of thrombosis.
