Research on compaction behavior of pharmaceutical powders based on surface free energy
10.16438/j.0513-4870.2017-0087
- VernacularTitle:基于表面自由能性质的物料压缩特性研究
- Author:
Liang-shan MING
1
;
Zhe LI
1
;
Fei WU
1
;
You-jie WANG
1
;
Ruo-fei DU
1
;
Li-jie ZHAO
1
;
Yi FENG
1
Author Information
1. Engineering Research Center of Modern Preparation of TCM, Ministry of Education, Shanghai 201203, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
surface free energy;
Heckel equation;
tensile strength;
contact angle;
cohesion work;
correlation analysis
- From:
Acta Pharmaceutica Sinica
2017;52(7):1170-1177
- CountryChina
- Language:Chinese
-
Abstract:
This study was designed to establish the method of characterization of surface free energy(SFE)and evaluate the compaction properties of pharmaceutical materials based on SFE. We investigated the contact angles of materials with water and diiodomethane under different compression pressures. The contact angles of materials at 353 MPa compression pressure were utilized to calculate the related parameters of SFE ultimately. The area under tensile strength-compression pressure curve(AUTSC)and pressure yield(Py)were employed to evaluate the compactibility of material. Additionally, Pearson correlation analysis was utilized to analyze the relationship between the SFE and the compaction properties of pharmaceutical materials. The results exhibited that SFE had a significant correlation with the compaction properties of materials(P < 0.05). Moreover, the related parameters of SFE, i.e., cohesive work(Wco)and polarity index(PI)of SFE, were positively correlated with Py of Heckel equation and negatively related with AUTSC. The higher values of Wco and PI, the stronger repulsive force among the particles, led to a worse compaction behavior. In this study, we established the method for characterization of the compaction behavior of materials based on SFE initially. This study also demonstrated that SFE could evaluate the compaction behavior effectively, which provides a better understanding of compaction behavior for pharmaceutical researchers.
