Stability of the new type of <i>L. Bulgaricus</i> microcapsule

Yi-xian Zhou; Feng LI; Bei Wang; Jing-tian Chen; Ying Huang; Xin Pan; Ge LI; Hang-ping Chen; Min Feng; Chuan-bin WU

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Stability of the new type of L. Bulgaricus microcapsule

VernacularTitle:新型保加利亚乳杆菌微胶囊的稳定性
Author: Yi-xian ZHOU ¹ ; Feng LI ¹ ; Bei WANG ¹ ; Jing-tian CHEN ¹ ; Ying HUANG ¹ ; Xin PAN ¹ ; Ge LI ² ; Hang-ping CHEN ² ; Min FENG ¹ ; Chuan-bin WU ¹
Author Information

1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
2. Guangzhou Neworld Pharmaceutical Co., Ltd., Guangzhou 510006, China
Publication Type:ORIGINAL ARTICLES
Keywords: probiotics; lactobacillus; capsule; drug stability
From: Acta Pharmaceutica Sinica 2017;52(7):1165-1169
CountryChina
Language:Chinese
Abstract: A new type of L. Bulgaricus microcapsule was prepared to improve stability and resistance of L.Bulgaricus probiotics in harsh environments. An optimal method of preparation of L. Bulgaricus microcapsule is as follow. L. Bulgaricus was mixed with 3% alginate solution. The concentration of bacterial suspension was 1×10⁹ cfu·mL^-1. The mixture was microencapsulated by extrusion into 2% CaCl₂ solution with a dispensing equipment. After 30 min solidification, the gel beads were lyophilized to obtain L.Bulgaricus microcapsules. The microencapsulation technology was aimed to improve the stability and survival rate of L. Bulgaricus. The microcapsule was spherical with uniform particle size and intact structure. The tolerance of acid, high temperature, high humidity and the long-term stability of freeze-dried powder and microcapsule were evaluated. The results indicated that microencapsulation technic could greatly improve stability and resistance of L. Bulgaricus probiotics in harsh environments.