Guaiane-type sesquiterpenes from the fruits of Fructus carotae
10.16438/j.0513-4870.2017-0129
- VernacularTitle:南鹤虱中愈创木烷型倍半萜类化学成分研究
- Author:
Gui-yuan LIU
1
;
Nan WEN
1
;
Mao-sheng ZHANG
1
;
Ying-shu XU
1
;
Shao-bin FU
1
;
Shi-ji XIAO
1
Author Information
1. School of Pharmacy, Zunyi Medical University, Zunyi 563000, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
Fructus carotae;
Daucus carota;
umbelliferae;
guaiane;
sesquiterpene;
chemical constituent
- From:
Acta Pharmaceutica Sinica
2017;52(7):1146-1149
- CountryChina
- Language:Chinese
-
Abstract:
To study the chemical constituents of the fruits of Fructus carotae, silica gel column chromatography and preparative HPLC were used to isolate and purify the extract of Fructus carotae. The structures of obtained compounds were elucidated on the basis of physicochemical property and spectral data. Nine guaiane-type sesquiterpenes were isolated and identified as 8β-angeloyloxy-11-hydroxy-4-guaien-3-one(1), 11-acetoxy-4-guaien-3-one(2), 11-acetoxy-8β-isobutyryl-4-guaien-3-one(3), 11-acetoxy-8β-propionyl-4-guaien-3-one(4), 11-hydroxy-4-guaien-3-one(5), 11-acetoxy-8β-angeloyloxy-1β-hydroxy-4-guaien-3-one(6), 11-acetoxy-8β-angeloyloxy-4-guaien-3-one(7), 11-acetoxy-8β-hydroxy-4-guaien-3-one(8)and 8β,11-dihydroxy-4-guaien-3-one(9). Compound 1 is a new compound, compound 5 is a new natural product, and compounds 2-4 were isolated from this genus for the first time.
