Synthesis and anti-HBV activity evaluation of Matijin-Su derivatives containing gallic acid moiety

VernacularTitle:含没食子酸单元的马蹄金素衍生物的合成及其抗HBV活性研究
Author: Yi LIU ¹ ; Wei LU ¹ ; Qing-chuan LIU ² ; Zheng-ming HUANG ² ; Guang-yi LIANG ³ ; Bi-xue XU ³
Author Information

1. College of Pharmacy, Guizhou University, Guiyang 550002, China
2. 302 Hospital of PLA, Beijing 100039, China
3. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medcial University, Guiyang 550014, China
Publication Type:ORIGINAL ARTICLES
Keywords: hepatitis B virus; derivative of Matijin-Su; synthesis; biological activity
From: Acta Pharmaceutica Sinica 2017;52(7):1140-1145
CountryChina
Language:Chinese
Abstract: In this study, eleven containing gallic acid moiety derivatives of Matijin-Su(MTS)were synthesized and evaluated for their anti-HBV activities in HepG2 2.2.15 cells in an effort to find novel effective anti-hepatitis B virus(HBV)agents. Compounds 5c, 6c and 6d exhibited significant anti-HBV activity with IC₅₀ values of 6.12, 8.44 and 9.86 μmol·L^-1, respectively. Incorporation of gallic acid moiety into MTS derivatives can lead to profound changes in their anti-HBV activity, and could be worth of further research.