Advance in research on cell-derived nanomedicine delivery system
10.16438/j.0513-4870.2017-0226
- VernacularTitle:细胞-纳米药物递送系统的研究进展
- Author:
Xuan-rong SUN
1
;
Long-chao ZHANG
1
;
Qi-wen SHI
1
;
Han-bing LI
1
;
Hang ZHAO
1
Author Information
1. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310006, China
- Publication Type:REVIEWS
- Keywords:
cell-derived nanomedicine delivery system;
cell membrane;
nanoparticle;
erythrocyte;
mononuclear phagocyte system;
tumor cell;
bacteria
- From:
Acta Pharmaceutica Sinica
2017;52(7):1110-1116
- CountryChina
- Language:Chinese
-
Abstract:
Nanoparticles hold great potential in the improvement of the therapeutic activities of many drugs. Synthetic approaches are dominant in the conventional approach for nanoparticles design and engineering strategies. However, combination of synthetic nanoparticles with natural biomaterials have recently gained much attention. By taking inspiration from nature, cell-derived nanomedicine delivery system has been created, which is a biomimetic platform consisting of a nanoparticulate core coated with cell or cell membrane. Compared to the conventional drug delivery systems, this novel system combines the unique functionalities of cells and engineering versatility of synthetic nanomaterials for effective delivery of therapeutic agents. With existing of cell, nanomedicine has significantly improved the biocompatibility, accurate delivery and long half-life in circulation as well as reduced the toxicity and side effect of drugs. Moreover, the delivery system can interact with the incredibly complex biological systems that exist within the body, such as actively targeting the inflammatory sites and tumors. Hence, it can be applied to drug delivery, tumor radiotherapy, and vaccine preparation. The cell-derived nanomedicine delivery system emerging as a novel delivery strategy, have the potential to significantly advance the nanomedicine to improve the therapeutic efficacy. The recent research in characteristics, preparation and application of erythrocyte, mononuclear phagocyte, bacteria and tumor cell as nanomedicine delivery carrier are reviewed.
