Preparation of mesoporous silica nanoparticles in different pore size and its use in the solidification of sirolimus loaded self-microemulsifying drug delivery system
10.16438/j.0513-4870.2016-1198
- VernacularTitle:不同孔径介孔二氧化硅纳米粒的制备及其用于固化西罗莫司自微乳
- Author:
Yue YU
1
;
Chun TAO
1
;
Hai-yue YANG
1
;
Tian-yu WANG
1
;
Dan-ping XUE
1
;
Xue-mei TIAN
1
;
Mei-jing ZHANG
1
;
Sheng-nan FANG
1
;
Hong-tao SONG
1
Author Information
1. Fuzhou General Hospital of Nanjing Command, PLA, Fuzhou 350025, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
sirolimus;
mesoporous silica nanoparticle;
self-microemulsifying drug delivery system;
solidification;
nano-carrier;
in vitro dissolution rate
- From:
Acta Pharmaceutica Sinica
2017;52(6):985-991
- CountryChina
- Language:Chinese
-
Abstract:
The mesoporous silica nanoparticles (MSN) in different pore size and sirolimus (SRL) loaded self-microemulsifying drug delivery system (SMEDDS) were prepared. The results in morphology were collected by scanning electron microscope, transmission electron microscope, small-angle X-ray diffraction, and N2 adsorption-desorption. The results showed that the prepared MSN has ordered nanochannels with a pore size of 6.3, 8.1, 10.8 nm, respectively. The particle size of SRL-SMEDDS were measured by particle sizing system, which was 20.6±1.3 nm. The stirring method was developed to prepare SRL-SMEDDS-MSN. It was found that the optimal ratio of SRL-SMEDDS to MSN was 2:1, while the drug loading rate was near 0.83%, and the flow properties of SRL-SMEDDS-MSN were of good condition. The differential scanning calorimetry results proving a molecular or amorphous dispersed state of SRL in MSN while the suspension experiment has shown great reconstitution properties of SRL-SMEDDS-MSN. There is no significant influence on maximum drug release rate of different pore size of SRL-SMEDDS-MSN in 250 mL water within 2 h, while the results of the first 40 min have an obvious difference. Above all, MSN might provide a new strategy for the solidification of SMEDDS.
