A review of radiation impact on drug metabolism
10.16438/j.0513-4870.2016-1152
- VernacularTitle:辐射影响药物代谢的研究进展
- Author:
Yi-jie QIAO
1
;
Yuan-yao XIN
2
;
Xue-jiao ZHOU
2
;
Meng YANG
2
;
Xiang-yang LI
1
Author Information
1. Medical College, Qinghai University, Xining 810001, China
2. College of Ecological and Environment Engineering, Qinghai University, Xining 810016, China
- Publication Type:REVIEWS
- Keywords:
radiation;
pharmacokinetics;
drug metabolism enzyme;
drug transporter
- From:
Acta Pharmaceutica Sinica
2017;52(6):871-878
- CountryChina
- Language:Chinese
-
Abstract:
The radiation is regarded as the fourth biggest pollution following the water, air and noise pollution, which generates a broad impact on human physiology and healthy. The radiation mainly comes from medical rays, industrial rays, nuclear wastes and atmospheric ultraviolet rays. The universality makes people pay more and more attention to the damage effect and mechanism of radiation. The radiation is divided into ionizing and non-ionizing radiation. It is a good idea to study the effect of ionizing and non-ionizing radiation on drug's metabolism, which may give a guidance to clinical medication to avoid adverse reactions and to support personalized medicine. This article reviews the effect of ionizing radiation (γ-rays, X-rays, uranium and cesium) and non-ionizing radiation (ultraviolet rays) on drug metabolism, their impact on metabolic characteristics of some drugs and the impact on expression of enzymes and transporters in drug metabolism, which is conducted with a focus on clinical significance.
